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Shaker, W., ghali, L., Hegazy, E. (2021). Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats. Dental Science Updates, 2(2), 175-184. doi: 10.21608/dsu.2021.60867.1065
Waleed Mohamed Shaker; laila sadek ghali; Enas Mahmoud Hegazy. "Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats". Dental Science Updates, 2, 2, 2021, 175-184. doi: 10.21608/dsu.2021.60867.1065
Shaker, W., ghali, L., Hegazy, E. (2021). 'Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats', Dental Science Updates, 2(2), pp. 175-184. doi: 10.21608/dsu.2021.60867.1065
Shaker, W., ghali, L., Hegazy, E. Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats. Dental Science Updates, 2021; 2(2): 175-184. doi: 10.21608/dsu.2021.60867.1065

Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats

Article 8, Volume 2, Issue 2, September 2021, Page 175-184  XML PDF (2.24 MB)
Document Type: Original Article
DOI: 10.21608/dsu.2021.60867.1065
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Authors
Waleed Mohamed Shaker email 1; laila sadek ghali2; Enas Mahmoud Hegazyorcid 3
1Oral biology, faculty of dentistry, south valley university, Qena, Egypt
2professor oral biology, dental college, cairo university dean of dental college sini university, qantara branch, egypt
3Oral biology, faculty of dentistry, Suez Canal University, ismaelia, Egypt
Abstract
ABSTRACT
Introduction: Periodontal disease is one of the main dental diseases that affect
millions of people around the world. Modern nanotechnology progression and
renovations through nanodentistry providing a suitable solution for the treatment of many
dental illnesses including periodontal disease. Aim: Histological and ultrastructural
evaluation of the effect of silver nanoparticles in treatment of periodontitis in albino
rats. Materials and methods: A total of 18 adults male albino rats with body weight
ranging from 150 to 180 gm were used and divided into three groups group 1: served as
control, group 2: used for induction of experimental periodontitis using wiring around
the cervix of mandibular central incisors for two weeks, and group 3: after induction of
experimental periodontitis as in group 2 they were subjected to intraperitoneal injection
with silver nanoparticles for the treatment of periodontitis three times per week for four
weeks. Results: Histological and ultrastructural investigation revealed that periodontal
ligament around ligated mandibular incisors showed marked improvement in the
degenerated fibers after injection with silver nanoparticles in group 3 compared to
group 2 as the fibers regained their association in strong bundles and they regained their
attachment to regenerated bone and tooth surface. Conclusions: Marked regeneration
of the periodontium of periodontally affected ligated mandibular incisors reflected that
silver nanoparticles have a great anti-inflammatory effect
Keywords
Albino rats; Histological; Periodontitis; Silver nanoparticles
Main Subjects
Oral biology
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