Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats

Shaker, Waleed Mohamed; Ghali, Laila Sadek; Hegazy, Enas Mahmoud

doi:10.21608/dsu.2021.60867.1065

Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats

Document Type : Original Article

Authors

¹ Oral biology, faculty of dentistry, south valley university, Qena, Egypt

² professor oral biology, dental college, cairo university dean of dental college sini university, qantara branch, egypt

³ Oral biology, faculty of dentistry, Suez Canal University, ismaelia, Egypt

10.21608/dsu.2021.60867.1065

Abstract

ABSTRACT
Introduction: Periodontal disease is one of the main dental diseases that affect
millions of people around the world. Modern nanotechnology progression and
renovations through nanodentistry providing a suitable solution for the treatment of many
dental illnesses including periodontal disease. Aim: Histological and ultrastructural
evaluation of the effect of silver nanoparticles in treatment of periodontitis in albino
rats. Materials and methods: A total of 18 adults male albino rats with body weight
ranging from 150 to 180 gm were used and divided into three groups group 1: served as
control, group 2: used for induction of experimental periodontitis using wiring around
the cervix of mandibular central incisors for two weeks, and group 3: after induction of
experimental periodontitis as in group 2 they were subjected to intraperitoneal injection
with silver nanoparticles for the treatment of periodontitis three times per week for four
weeks. Results: Histological and ultrastructural investigation revealed that periodontal
ligament around ligated mandibular incisors showed marked improvement in the
degenerated fibers after injection with silver nanoparticles in group 3 compared to
group 2 as the fibers regained their association in strong bundles and they regained their
attachment to regenerated bone and tooth surface. Conclusions: Marked regeneration
of the periodontium of periodontally affected ligated mandibular incisors reflected that
silver nanoparticles have a great anti-inflammatory effect

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