Swidan, S., Hassan, M., El mansy, M. (2021). Synergistic Therapeutic Effect of Honokiol and 5-Fluorouracil on the Induced-Tongue Cancer in Rats.. Dental Science Updates, 2(1), 61-68. doi: 10.21608/dsu.2021.27204.1035
Sara Ali Swidan; Magda Hassan; Merhan El mansy. "Synergistic Therapeutic Effect of Honokiol and 5-Fluorouracil on the Induced-Tongue Cancer in Rats.". Dental Science Updates, 2, 1, 2021, 61-68. doi: 10.21608/dsu.2021.27204.1035
Swidan, S., Hassan, M., El mansy, M. (2021). 'Synergistic Therapeutic Effect of Honokiol and 5-Fluorouracil on the Induced-Tongue Cancer in Rats.', Dental Science Updates, 2(1), pp. 61-68. doi: 10.21608/dsu.2021.27204.1035
Swidan, S., Hassan, M., El mansy, M. Synergistic Therapeutic Effect of Honokiol and 5-Fluorouracil on the Induced-Tongue Cancer in Rats.. Dental Science Updates, 2021; 2(1): 61-68. doi: 10.21608/dsu.2021.27204.1035
Synergistic Therapeutic Effect of Honokiol and 5-Fluorouracil on the Induced-Tongue Cancer in Rats.
1oral pathology, faculty of dentistry, Suez canal university, Ismailia, Egypt
2oral pathology, faculty of dentistry, suez canal university, Ismailia, Egypt
Abstract
Introduction: 5-Fluorouracil (5-FU) is a common chemotherapeutic drug for treatment of oral squamous cell carcinoma. However, its toxicity to normal tissues has limited its role as an effective cancer therapy. Aim: This research aimed to investigate the effect of combining 5-FU with honokiol (HNK) on enhancing the anticancer activity of 5-FU without increasing its toxicity. Material and methods: HNK was used in combination with 5-FU for treatment of tongue carcinoma induced chemically by 4-nitroquinoline 1 oxide (4-NQO) in albino rats. Rats were divided into five groups (10 animals each) including control, 4-NQO, 5-FU, HNK, and combined 5-FU with HNK. Serial sections of the tongues from all animals were examined microscopically and real-time PCR quantification of P53 gene expression was also assessed. Results: The results showed that treatment with both 5-FU + HNK had significantly regressed the number and size of malignant lesions seen in the carcinogen-only group. Data analysis revealed a statistically significant decrease in the expression levels of mutant P53 in the combined treatment group compared to control groups. Conclusion: This study reported that HNK and 5-FU had a synergistic cytotoxic effect on this model, without notable intensification of the side effects associated with 5-FU treatment. Introduction: 5-Fluorouracil (5-FU) is a common chemotherapeutic drug for treatment of oral squamous cell carcinoma. However, its toxicity to normal tissues has limited its role as an effective cancer therapy. Aim: This research aimed to investigate the effect of combining 5-FU with honokiol (HNK) on enhancing the anticancer activity of 5-FU without increasing its toxicity. Material and methods: HNK was used in combination with 5-FU for treatment of tongue carcinoma induced chemically by 4-nitroquinoline 1 oxide (4-NQO) in albino rats. Rats were divided into five groups (10 animals each) including control, 4-NQO, 5-FU, HNK, and combined 5-FU with HNK. Serial sections of the tongues from all animals were examined microscopically and real-time PCR quantification of P53 gene expression was also assessed. Results: The results showed that treatment with both 5-FU + HNK had significantly regressed the number and size of malignant lesions seen in the carcinogen-only group. Data analysis revealed a statistically significant decrease in the expression levels of mutant P53 in the combined treatment group compared to control groups. Conclusion: This study reported that HNK and 5-FU had a synergistic cytotoxic effect on this model, without notable intensification of the side effects associated with 5-FU treatment.
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