ADJUNCTIVE EFFECT OF PROPOLIS GEL TO NON-SURGICAL STAGE II PERIODONTITIS THERAPY: A CLINICAL AND IMMUNOLOGICAL STUDY

Dawoud, Aya; Ali, Mohamed; Azzab, Marwa Mohamed; Hashem, Abdel Nasser Mohammed

doi:10.21608/dsu.2025.323872.1282

ADJUNCTIVE EFFECT OF PROPOLIS GEL TO NON-SURGICAL STAGE II PERIODONTITIS THERAPY: A CLINICAL AND IMMUNOLOGICAL STUDY

Document Type : Original Article

Authors

¹ oral medicine and periodontology, Suez Canal university, Ismailia, Egypt

² oral medicine and periodontology, Suez Canal University

³ professor of microbiology and immunology, faculty of pharmacy, Suez Canal university

⁴ oral medicine and periodontology department, faculty of dentistry, suez canal university

10.21608/dsu.2025.323872.1282

Abstract

ABSTRACT
Introduction: Periodontitis affects more than 1/2 of adults over the age of 30.
Scaling and root planning is a non-surgical, gold standard that determines important
objectives to control bacterial infections and reduce inflammation related to periodontal
plaque. In recent years, natural products have become increasingly popular; Propolis
is a natural material produced by bees and ieffective in treating periodontal disease.
Aim: This study was designed to evaluate the effect of propolis gel as an adjunctive
non-surgical treatment on improving clinical parameters (PI, GI) and reducing proinflammatory
mediator (IL1, IL6) levels in stage II periodontitis. Methodology: Sixty
patients with stage II periodontitis will be selected from the out- patient clinic of Oral
Medicine and Periodontology Department, Faculty of Dentistry, Suez Canal University.
Moreover, it will be divided randomly into two equal groups. Control group: will receive
scaling and root planning only. Test Group: will receive scaling and root planning and
propolis gel adjunctive to non-surgical therapy. At baseline, 1 month and 3 months and
for each group clinical parameters (PI, GI) assessed and proinflammatory mediators
(IL1, IL6). Results in the intergroup comparison of IL1 and IL6 levels at different time
intervals, the propolis group showed a statistically significant decrease in IL1 and IL6
levels compared to the SRP. The mean IL-1 was lower in the study group than in the
control group after 1 month and 3 months. (p-value). In the intergroup comparison of
clinical parameters (Gingival index, plaque index) at different time intervals there is
no statistically significant difference. Conclusion: Subgingival delivery of propolis gel
showed enhanced results as an adjunct to SRP in patients with stage II periodontitis as
assessed by clinical and biochemical parameters.

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