Impact of Oxford vaccine during pregnancy on tooth germ development and hard tissue thickness in the albino rats offspring

Document Type : Original Article

Authors

1 Department of Oral Biology, Faculty of dentistry, Suez Canal University

2 Department of Oral Biology, Faculty of Dentistry, Suez Canal University

3 Oral Biology, Faculty of Dentistry, Suez Canal University

Abstract

Introduction: Teeth development and eruption are complicated events
embracing plenty of structures and signaling pathways. Severe acute respiratory
syndrome coronavirus-2 is the causative agent of coronavirus infectious disease-2019
(COVID-19). Pregnant females infected with COVID-19 have disturbances in the
inflammatory reaction that would lead to a severe disease; therefore, their vaccination
is obligatory. Materials and Methods: Pregnant female rats were equally distributed
into two groups: Control group received saline and treated group received COVID-19
vaccine. At the proposed time, pups were euthanized, and the mandible of each pup was
dissected for histological examination. Histomorphometric examination was performed
for the thickness of enamel and dentin of the lower first molar on the 9th and 14th
postnatal days. Results: Developmental stages of the lower first molar tooth germ in
both groups were nearly comparable with no histological differences. Enamel thickness
increased in a non-statistically significant manner in the treated group (P-value ≥ 0.05)
while dentin thickness increased in a statistically significant manner in the treated group
at the same time points (P-value ≤ 0.05). Conclusion: Vaccination of pregnant mothers
did not influence the development of lower first molar tooth germ in the offspring.
However, hard tissue thickness may be affected by vaccination.

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Dental Science Updates
Volume 6, Issue 2
September 2025
Pages 441-450

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