Efficacy of Hyaluronic Acid Injection Locally on Postoperative Complications after Surgical Removal of Impacted Mandibular Third Molars

Document Type : Original Article

Authors

1 Oral and maxillofacial surgery Faculty of Dentistry suez canal University

2 faculty of dentistry , suez canal university

3 Department of Oral and Maxillofacial surgery, faculty of dentistry, Suez Canal University

Abstract

Introduction: Odontectomy is a popular dental surgery treatment. However,
nerve injury, bone fractures, delayed healing, inflammation, soreness, edema, and
trismus might result. These conditions lower patient quality of life. Many research
reduced post impacted tooth surgical problems. Hyaluronan (HA) is a biomaterial that
accelerates wound healing. Aim: to evaluate efficacy of Hyaluronic acid injection
locally on control of swelling, pain and trismus in surgical removal of impacted
mandibular third molars. Patients and methods: This study was a randomized clinical
control trial and was conducted on 20 adult healthy patients who required surgical
extraction of impacted lower third molar with bilateral, symmetrical lower impacted
third molars that need surgical extraction. Each patient has two sides (right and left
side) one of them was treated by experimental materials (Group B) and the other side
was left without treatment as a control group. Results: The overall difference in VAS
was significant according to groups, Time points, and interaction between groups and
time). Truisms mouth opening (TMO) in the control group showed an average (±SD)
of 40.87±7.97, 29.11±9.88, 34.50±8.55, 40.97±8.18; respectively. However, The TMO
in the treated group showed an average (±SD) of 40.87±7.97, 34.50±8.07, 37.80±6.46,
and 41.38±7.81; respectively. The linear relationship in TMO with time showed a direct
(positive) relationship as revealed by simple linear regression. The mean swelling
parameters in the control group showed an average (±SD) of 10.51±0.85, 12.12±0.89,
11.34±0.54, and 10.76±0.58; respectively. However, the mean swelling parameters in
the treated group and showed an average (±SD) of 10.51±0.85, 11.24±0.78, 10.64±0.85,
and 10.17±0.45; respectively. Regression trendline showing the linear correlation
between time and mean swelling parameters. Conclusion: HA injection after extraction
of impacted mandibular third molars has a positive effect on postoperative pain, trismus
and swelling. 

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