El-Halwagy, M., Hegazy, E., Shalaby, H., Mahmoud, E. (2025). INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS. Dental Science Updates, 6(1), 111-122. doi: 10.21608/dsu.2025.315963.1254
Mai Osman El-Halwagy; Enas Mahmoud Hegazy; Hany Kamel Shalaby; Elham Fathy Mahmoud. "INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS". Dental Science Updates, 6, 1, 2025, 111-122. doi: 10.21608/dsu.2025.315963.1254
El-Halwagy, M., Hegazy, E., Shalaby, H., Mahmoud, E. (2025). 'INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS', Dental Science Updates, 6(1), pp. 111-122. doi: 10.21608/dsu.2025.315963.1254
El-Halwagy, M., Hegazy, E., Shalaby, H., Mahmoud, E. INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS. Dental Science Updates, 2025; 6(1): 111-122. doi: 10.21608/dsu.2025.315963.1254
INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS
3Oral Medicine and Periodontology Department, Faculty of Dentistry, Suez University, Suez, Egypt.
Abstract
Introduction: Osteoporosis is a bone disorder with significant alterations in bone biologic material and consequent bone structural distraction. Low-level laser therapy (LLLT) has been studied as a physical modality that influences cellular activity through photochemical, photophysical, and photobiological mechanisms, making it an effective intervention for osteoporosis. Aim of the study: The current study was conducted to evaluate the impacts of low-level laser therapy on glucocorticoid induced osteoporosis at different time intervals. Methodology: This investigation involved 40 adult male albino rats, which were evenly distributed into four groups, each containing ten rats; control, DEX, 7 days LLLT, and 25 days LLLT. At the end of the experiment, all the rats were humanely euthanized. Their lower jaws were then collected and subjected to staining with Hematoxylin & Eosin (H&E) and immunohistochemical (IHC) analysis for RANKL and OPG. Results: DEX group revealed massive alveolar bone destruction with strong RANKL and weak OPG immunoreactivities. However, 7 days LLLT and 25 days LLLT groups showed improvements in the alveolar bone architecture with decreased RANKL and increased OPG immunoreactivities. Conclusion: Through RANKL/OPG ratio downregulation, LLLT improved bone architecture, encouraged bone healing, and stimulated osteogenesis over time.
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