Mohammed, Y., Taha, R., Ghali, L. (2021). Effect of statins on the periodontal ligament and Alveolar process of induced Diabetic Rats. Dental Science Updates, 2(1), 9-16. doi: 10.21608/dsu.2021.21285.1024
Yasser Abd-Elraouf Mohammed; Rasha Mohamed Taha; Laila Sadek Ghali. "Effect of statins on the periodontal ligament and Alveolar process of induced Diabetic Rats". Dental Science Updates, 2, 1, 2021, 9-16. doi: 10.21608/dsu.2021.21285.1024
Mohammed, Y., Taha, R., Ghali, L. (2021). 'Effect of statins on the periodontal ligament and Alveolar process of induced Diabetic Rats', Dental Science Updates, 2(1), pp. 9-16. doi: 10.21608/dsu.2021.21285.1024
Mohammed, Y., Taha, R., Ghali, L. Effect of statins on the periodontal ligament and Alveolar process of induced Diabetic Rats. Dental Science Updates, 2021; 2(1): 9-16. doi: 10.21608/dsu.2021.21285.1024
Effect of statins on the periodontal ligament and Alveolar process of induced Diabetic Rats
1Oral Biology, Faculty of Dentistry, South Valley University, Qena, Qena
2Oral Biology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.
3Oral Biology, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt
Abstract
Introduction: Considering the Diabetes mellitus (DM) as one of the oldest conditions characterized in humans, it has been recognized since antiquity and considered as a major health problem at present. There is a need for efficient treatment. Aim: The aim of the present investigation was to find out whether statins can alleviate the well documented side effects of Streptozotocin induced diabetes mellitus on the periodontal ligament of adult male Albino rats. Materialand Methods: Sixty adult male albino rats with body weight ranging from180-200gr were used in this investigation. They were divided into the following groups. Group 1: consisted of 20 animals and served as controls. Group 2: consisted of 20 animals, they were subjected to a single intraperitoneal injection of streptozotocin in a dose 60 mg/kg body weight of for induction of diabetes mellitus. Group 3: consisted of 20 animals. They were subjected to induction of diabetes mellitus in the same way as group 2 animals. One week later, the animals were treated with simvastatin in a daily intraperitoneal dose of 5mg/kg body weight. At the end of the experiment the animals were sacrificed by cervical dislocation, their Jaws were dissected out then processed for the histological and transmission electron microscopic examinations. Results: The present work showed that the treatment of diabetic rats with statins resulted in amelioration of the degenerative effect of diabetes on the periodontal ligament when compared with. Changes of diabetes in group 2 and regenerative changes of statins in group 3 compared to the control group 1. Conclusion: Diabetic albino rats treated with statins revealed partial improvements, mostly in the arrangement of the fibers of periodontal ligament.
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