Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Histological study on the effect of the immunosuppressive drugs on the mucous membrane and salivary glands of the treated rats tongues1715278810.21608/dsu.2021.18795.1013ENLoaa Diaa El-dinMahmoudoral biology department, future universityLaila SadekGhaliProfessor of Oral Biology,
Faculty of Oral and Dental
Medicine, Cairo UniversityManar SelimAssociate professor of Oral
biology, Faculty of Dentistry,
Suez Canal University.Journal Article20191028<strong>Introduction</strong>: Tacrolimus is a macrolide calcineurin inhibitor which has been shown to decrease acute and chronic rejection, improved renal function over the longterm post-transplant. Tacrolimus is considered the drug of choice in immunosuppressive therapy for chronic diseases irresponsive to corticosteroids, autoimmune diseases and organ transplantation system. <strong>Aim</strong>: The aim of the investigation was to study the effect of the immunosuppressive drug Tacrolimus on the lingual mucous membrane and salivary glands of treated rats through hematoxylin and eosin stained sections to detect any microscopic changes in the structure of the mucous membrane and salivary glands of the tongues & Masson’s trichrome stained sections for detection of the integrity of collagen. <strong>Material and Methods:</strong> Thirty healthy adult male albino rats with body weight ranging from 150 to 180 gm were used in this investigation. The animals were divided into two groups 15 animals each. Group 1: served as control, group 2: animals were treated with the immunosuppressive drug tacrolimus dissolved in distilled water in a daily oral dose of 0.5 mg/kg body weight. At the end of the experiment the rats of different groups were euthanized by cervical dislocation. The tongues were dissected out, fixed, processed, embedded in paraffin, sectioned and stained with hematoxylin and eosin for histological evaluation & Masson’s trichrome stain for demonstration of collagen fibers. <strong>Results</strong>: The light microscopic examination of group I showed the normal histological features of both surface epithelium and underlying lamina propria, while group II Treated with tacrolimus revealed atrophic and degenerative changes that involved the surface epithelium and lamina propria of both the dorsal and ventral surfaces of the tongue as well as the lingual salivary glands. <strong>Conclusion</strong>: Tacrolimus administration showed structural alterations in the lingual mucous membrane and the lingual salivary glands which will certainly affect the taste sensation.Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Effect of statins on the periodontal ligament and Alveolar process of induced Diabetic Rats91615289110.21608/dsu.2021.21285.1024ENYasser Abd-ElraoufMohammedOral Biology, Faculty of Dentistry, South Valley University, Qena, QenaRasha MohamedTahaOral Biology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.Laila SadekGhaliOral Biology, Faculty of Oral and Dental Medicine, Cairo University, Cairo, EgyptJournal Article20200203<strong>Introduction</strong>: Considering the Diabetes mellitus (DM) as one of the oldest conditions characterized in humans, it has been recognized since antiquity and considered as a major health problem at present. There is a need for efficient treatment. <strong>Aim</strong>: The aim of the present investigation was to find out whether statins can alleviate the well documented side effects of Streptozotocin induced diabetes mellitus on the periodontal ligament of adult male Albino rats. <strong>Material</strong> <strong>and Methods</strong>: Sixty adult male albino rats with body weight ranging from180-200gr were used in this investigation. They were divided into the following groups. Group 1: consisted of 20 animals and served as controls. Group 2: consisted of 20 animals, they were subjected to a single intraperitoneal injection of streptozotocin in a dose 60 mg/kg body weight<br />of for induction of diabetes mellitus. Group 3: consisted of 20 animals. They were subjected to induction of diabetes mellitus in the same way as group 2 animals. One week later, the animals were treated with simvastatin in a daily intraperitoneal dose of 5mg/kg body weight. At the end of the experiment the animals were sacrificed by cervical dislocation, their Jaws were dissected out then processed for the histological and transmission electron microscopic examinations. <strong>Results</strong>: The present work showed that the treatment of diabetic rats with statins resulted in amelioration of the degenerative effect of diabetes on the periodontal ligament when compared with. Changes of diabetes in group 2 and regenerative changes of statins in group 3 compared to the control group 1. <strong>Conclusion</strong>: Diabetic albino rats treated with statins revealed partial improvements, mostly in the arrangement of the fibers of periodontal ligament.Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Clinical and Radiographic Evaluation of Immediate Implant with Bone Graft (Hypro-oss)172515289710.21608/dsu.2021.23862.1025ENMona AbdelkaderAbasOral and Maxillofacial Surgery, Faculty of Dentistry, Suez Canal University, Ismailia, EgyptWalid AhmedGhanemProfessor Oral and Maxillofacial
Surgery, Faculty of Dentistry,
Suez Canal University.Gihan El DesoukyProfessor Oral Radiology,
Faculty of Dentistry, Suez
Canal UniversityYasser MohamedEl GerbyLecturer of Oral and Maxillofacial
Surgery, Faculty of Dentistry,
Suez Canal University.Journal Article20201001
<strong>Introduction: </strong>Xenograft play role in osseointegration of immediate dental implant. <strong>Aim of the study: </strong>to evaluate the efficiency of xenograft (Hypro-oss) in osseointegration of immediate dental implant clinically and radiographically. <strong>Patients and methods: </strong>This study conducted on 8 patients range from 18-48 years old. 12 immediate dental implants divided into two equal groups; (Control Group): Atraumatic extraction of single rooted tooth or remaining root and immediate placement of dental implant, (Study Group): Atraumatic extraction of single rooted tooth or remaining root and immediate placement of dental implant and sealed with Hypro-Oss bone graft material. Clinical examinations done for all patients prior to surgery include examination of oral and para oral tissues and evaluation the intermaxillary space and the type of occlusion. Radiographic evaluation using CBCT done in the intervals 15, 90, 180 and 270 days postoperatively to measure the bone density of the formed bone between living bone and the implant surface. <strong>Result: </strong>All the patients showed no signs or symptoms of pain, tenderness, redness or inflammation of soft tissue around the inserted implant site. Normal healing process of the soft tissue and bone around the implant. All patients continued the follow up period. Radiographic evaluation showed significant higher bone density in study group than control group after 15, 90, 180 and 270 days. <strong>Conclusion</strong>: With the use of Hypro-Oss bone graft, the bone density around the implant showed increase in values.Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Effect of mesenchymal bone marrow stem cells on the periodontal ligament of induced Diabetic Rats.273415290110.21608/dsu.2021.23966.1026ENYasser Abd-ElraoufMohammedOral Biology, Faculty of Dentistry, South Valley University, Qena, QenaRasha MohamedTahaOral Biology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.Laila SadekGhaliOral Biology, Faculty of Oral and Dental Medicine, Cairo University, Cairo, EgyptJournal Article20200213
<strong>Introduction: </strong>Considering the Diabetes mellitus (DM) as one of the oldest conditions characterized in humans, it has been recognized since antiquity and considered as a major health problem at present. There is a need for efficient treatment. <strong>Aim</strong>: The aim of the present investigation was to find out whether stem cells can alleviate the well documented side effects of streptozotocin induced diabetes mellitus on the periodontal ligament of adult male albino rats. <strong>Material and Methods: </strong>Sixty adult male albino rats with body were used in this investigation. They were divided into the following three groups; Group 1: consisted of 20 animals and served as controls; Group 2: consisted of 20 animals, they were subjected to a single intraperitoneal injection of streptozotocin in a dose of 60mg. /kg body weight for induction of diabetes mellitus; Group 3: consisted of 20 animals. They were subjected to induction of diabetes mellitus in the same way as group 2 animals. One week later, the animals were subjected to a single intravenous infusion of mesenchymal bone marrow stem cells. At the end of the experiment one week later the animals were euthanized by cervical dislocation, their jaws dissected out, decalcified then processed for A. histological examination (Hematoxylin and Eosin stain) B. transmission electron microscope. <strong>Results: </strong>Histological examination in the present work showed that the treatment of diabetic rats with stem cells resulted in amelioration of the degenerative effects of diabetes on the periodontal ligament in group 2 and regenerative changes of stem cells in group 3 compared to the control group 1. Electron microscopic examination of the PDL showed marked regenerative changes in the density of collagen. <strong>Conclusion: </strong>Diabetic albino rats treated with stem cells revealed partial improvements, mostly in the arrangement of the fibers of periodontal ligament. The ultrastructural features showed normal fibroblasts.Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Clinical Evaluation of Intra-articular Injections of Platelet Rich Plasma Versus Dextrose Prolotherapy for Management of Temporomandibular Joint Internal Derangement354615291210.21608/dsu.2021.24255.1028ENYasser FekryHabakaOral surgery department, faculty of dentistry, October 6 University, Giza, EgyptEman Al SharawyOral and Maxillofacial surgery department, Faculty of Dentistry, Suez Canal UniversityTamer Baryoral and maxillofacial surgery, swez canal university, EgyptAbdelbadia AbdelmaboodOral and Maxillofacial surgery, Faculty of Dentistry, Zagazig University .Journal Article20200701<strong>Introduction</strong>: TMJ internal derangement is characterized by intra-articular disc displacement resulting in popping or clicking sounds. The displacement of articular disc does not always cause a mechanical obstruction. Those conditions may be with or without pain. <strong>Aim: </strong>The aim of the study was to evaluate the clinical effect of intra-articular injections of platelet rich plasma for management of TMJ internal derangement through comparative study with dextrose prolotherapy. <strong>Patients and Methods: </strong>included 87 joints in 45 adult patients complaining pain, clicking in the Temporo-mandibular joint (internal derangement), pre-operative MRI was done for all patients with further clinical, radiographic as well as TMJ examination. Patients were divided into three equal groups randomly. <strong>Group I: (study group) </strong>composed of 15 patients where 1ml of platelet rich plasma was injected intra-articular (once) <strong>Group II: (study group) </strong>composed of 15 patients where 1ml of platelet rich plasma was injected intra-articular (twice) with one month interval <strong>Group III: (control group) </strong>composed of 15 patients where dextrose prolotherapy was injected (4 times) at 2 weeks, 4 weeks and 6 weeks intervals over a total of 12 weeks. Clinical assessment was done including MIO, pain, deviation and clicking. <strong>Results: </strong>statistically analysis of this study showed that group I, III showed the highest MIO values as well as VAS scores in the 3,6 and 12 months, however group II showed the lowest MIO in the same follow up period. <strong>Conclusions: </strong>PRP and Prolotherapy are successful techniques for treatment of symptoms related to internal derangement of TMJ.Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Comparative study between Sodium hyaluronic acid and dextrose prolotherapy in management of Temporo-mandibular joint internal derangement.475415292310.21608/dsu.2021.24268.1029ENYasser FekryHabakaOral surgery department, faculty of dentistry, October 6 University, Giza, EgyptEman Al SharawyOral and Maxillofacial surgery department, Faculty of Dentistry, Suez Canal UniversityTamer Baryoral and maxillofacial surgery, swez canal university, EgyptAbdelbadia AbdelmaboodOral and Maxillofacial surgery, Faculty of Dentistry, Zagazig University .Journal Article20200701<span class="A1"><strong>Introduction:</strong></span><span class="A1"> Internal derangements of TMJ were nonsurgical treated in initial stages with medications, physiotherapy and occlusal splints. Intra articular injection of corticosteroids alone or after arthrocentesis provides long-term palliative effects on clinical signs and subjective symptoms of TMJ pain.</span> <span class="A1"><strong>Aim: </strong></span><span class="A1">The study was done to compare between hyaluronic acid and dextrose prolotherapy in management of temporomandibular joint internal derangement. <strong>Patients and methods: </strong>The present study included 30 adult patients suffering from internal derangement of Temporo-mandibular joint were selected from outpatient clinic, oral and maxillofacial surgery department in faculty of dentistry, Suez Canal University as well as October 6 university. <strong>Group I: </strong>Composed of 15 patients (10 females, 5 males) where hyaluronic acid was injected intra-articular. <strong>Group II: </strong>Composed of 15 patients (9 females, 6 males) where dextrose prolotherapy was injected (4 times) at 2 weeks, 4 weeks and 6 weeks intervals over a total of 12 weeks. <strong>Results: </strong>No difference between Group I and II; both showed the highest mean MIO values. Group I and Group II; both showed lower mean of VAS scores after 12 months compared to pre-operative measurement. After 6 months, Group II showed the highest prevalence of deviation followed by Group I. <strong>Conclusion: </strong>Sodium hyaluronic acid and Prolotherapy is a successful technique to improve maximum inter-incisal opening as well as assisted interincisal opening and improved higher significant changes in pain intensity.</span>Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Effect of Single Session of Low-Level Laser Therapy on Pain, Swelling, and Trismus after Surgical Extraction of Impacted Lower Third Molar : A Clinical Study556015292510.21608/dsu.2021.25822.1030ENMina KamalGirgisOral and maxillofacial surgery , faculty of dentistry , suez canal university28802141602815Eman ElsharrawyProfessor of Anesthesiology in Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Suez Canal UniversityMohamed HassanLecturer inOral and Maxillofacial
Surgery, Faculty of
Dentistry, Suez Canal UniversityJournal Article20200313
<strong>Introduction: </strong>Low-level laser therapy (LLLT) can promote and accelerate the tissue regeneration as it causes the early healing of extraction sockets but the accurate mechanism is unknown. <strong>Aim: </strong>The study aimed to evaluate the effect of LLLT which was applied in a single session immediately after odontectomy of impacted lower wisdom tooth on pain, swelling, and trismus. <strong>Patient and Methods: </strong>This study was done on 24 healthy patients who required surgical extraction of impacted lower third molar. The patients were randomly selected and randomly divided into two equal groups, each consisted of 12 patients for group, group I received LLLT immediately after surgical extraction of impacted lower third molar, group II was subjected to routine surgical extraction of impacted lower third molar without application of LLLT. LLLT was applied at ten points: four intra-oral beside to the extracted socket and six extra-oral along the masseter muscle. Laser energy was applied at 100mW for a total of 150 sec, 15 sec for each point. <strong>Results: </strong>The results showed the effect of a single session of LLLT in control of postoperative pain on the day of surgery and reduction of swelling and trismus after surgical removal of impacted lower third molars (p < 0.05). <strong>Conclusion: </strong>LLLT could represent a viable tool to control pain in patients who are contraindicated to the medications.Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Synergistic Therapeutic Effect of Honokiol and 5-Fluorouracil on the Induced-Tongue Cancer in Rats.616815292710.21608/dsu.2021.27204.1035ENSara AliSwidanoral pathology, faculty of dentistry, Suez canal university, Ismailia, EgyptMagda Hassanoral pathology, faculty of dentistry, Suez canal university, Ismailia, EgyptMerhan El Mansyoral pathology, faculty of dentistry, suez canal university, Ismailia, EgyptJournal Article20200403<strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Introduction</span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">: 5-Fluorouracil (5-FU) is a common chemotherapeutic drug for treatment of oral squamous cell carcinoma. However, its toxicity to normal tissues has limited its role as an effective cancer therapy. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Aim: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">This research aimed to investigate </span><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">the effect of combining 5-FU with honokiol (HNK) on enhancing the anticancer activity of 5-FU without increasing its toxicity. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Material and methods: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">HNK was used in combination with 5-FU for treatment of tongue carcinoma induced chemically by </span><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">4-nitroquinoline 1 oxide (4-NQO) in albino rats. Rats were divided into five groups (10 animals each) including control, 4-NQO, 5-FU, HNK, and combined 5-FU with HNK. Serial sections of the tongues from all animals were examined microscopically and </span><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">real-time PCR quantification of P53 gene expression was also assessed. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Results</span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">: The results showed that treatment with both 5-FU + HNK had significantly regressed the number and size of malignant lesions seen in the carcinogen-only group. Data analysis </span><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">revealed a statistically significant decrease in the expression levels of mutant P53 in the combined treatment group compared to control groups. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Conclusion: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">This study reported that HNK and 5-FU had a synergistic cytotoxic effect on this model, without </span><span style="font-size: 9.0pt; line-height: 107%; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">notable intensification of the side effects associated with 5-FU treatment.</span>
<strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Introduction</span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">: 5-Fluorouracil (5-FU) is a common chemotherapeutic drug for treatment of oral squamous cell carcinoma. However, its toxicity to normal tissues has limited its role as an effective cancer therapy. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Aim: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">This research aimed to investigate</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">the effect of combining 5-FU with honokiol (HNK) on enhancing the anticancer activity of 5-FU without increasing its toxicity. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Material and methods: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">HNK was used in combination with 5-FU for treatment of tongue carcinoma induced chemically by</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">4-nitroquinoline 1 oxide (4-NQO) in albino rats. Rats were divided into five groups (10 animals each) including control, 4-NQO, 5-FU, HNK, and combined 5-FU with HNK. Serial sections of the tongues from all animals were examined microscopically and</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">real-time PCR quantification of P53 gene expression was also assessed. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Results</span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">: The results showed that treatment with both 5-FU + HNK had significantly regressed the number and size of malignant lesions seen in the carcinogen-only group. Data analysis</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">revealed a statistically significant decrease in the expression levels of mutant P53 in the combined treatment group compared to control groups. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Conclusion: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">This study reported that HNK and 5-FU had a synergistic cytotoxic effect on this model, without</span>
<span style="font-size: 9.0pt; line-height: 107%; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">notable intensification of the side effects associated with 5-FU treatment.</span>
Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Evaluation of Some Salivary Parameters in a Group of Children Suffering From Rampant Caries in Ismailia City697515292910.21608/dsu.2021.32325.1039ENEman Aboellielpediatric dentistry department ,faculty of dentistry ,suez canal university,ismailia ,egyptGhada Abd ElhamedElbazpediatric,preventive dentistry and dental public health,faculty of dentistry,suez canal universityNagwan Abd El Aziz MohamedSabekBiochimestry department, faculty of medicine,suez canal universityAsmaa AliABO ELSOUDPediatric, Preventive Dentistry and Dental Public Health
Faculty of Dentistry
Suez Canal UniversityJournal Article20200903<strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Introduction: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">Rampant caries (RC) is a severe form of dental decay with multifactorial origin. RC poses a challenging management problem for dentists and patients. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Aim: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">the aim of the study was to evaluate and compare between some salivary parameters: pH, buffering capacity, total protein, flow rate and zinc concentration in a group of children suffering from rampant caries and others with normal caries activity in Ismailia city. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Material and methods: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">sixty apparently healthy children aged from 3-5 years of both sexes. According to dmfs index the selected children were divided into three groups. Saliva samples were examined for salivary pH changes, measured by pH meter, Buffering capacity by titratable acidity, Total protein by colorimetric method, Flow rate by drooling method and Zinc concentration using an atomic absorption spectrophotometer. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Results: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">there was no statistically significant difference between mean salivary pH values in three groups. Salivary buffering capacity results showed, group I had a statistically significantly highest mean buffering capacity, There was no statistically significant difference between group II and group III, salivary total proteins showed no statically significant difference between group I and group II; both showed the statistically significant highest mean total protein, but group III showed the statistically significant lowest mean salivary total protein. There was no statistically significant difference between the three groups in salivary flow rate and Zn concentration. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Conclusion: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">salivary pH, flow rate and Zn conc. can’t be used as an indicator for occurrence of rampant caries but salivary total protein and salivary buffering capacity may be used.</span>
<strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Introduction: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">Rampant caries (RC) is a severe form of dental decay with multifactorial</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">origin. RC poses a challenging management problem for dentists and</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">patients. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Aim: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">the aim of the study was to evaluate and compare between some salivary</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">parameters: pH, buffering capacity, total protein, flow rate and zinc concentration in a</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">group of children suffering from rampant caries and others with normal caries activity</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">in Ismailia city. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Material and methods: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">sixty apparently healthy children aged from</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">3-5 years of both sexes. According to dmfs index the selected children were divided</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">into three groups. Saliva samples were examined for salivary pH changes, measured</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">by pH meter, Buffering capacity by titratable acidity, Total protein by colorimetric</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">method, Flow rate by drooling method and Zinc concentration using an atomic</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">absorption spectrophotometer. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Results: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">there was no statistically significant difference</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">between mean salivary pH values in three groups. Salivary buffering capacity results</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">showed, group I had a statistically significantly highest mean buffering capacity, There</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">was no statistically significant difference between group II and group III, salivary</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">total proteins showed no statically significant difference between group I and group < /span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">II; both showed the statistically significant highest mean total protein, but group III</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">showed the statistically significant lowest mean salivary total protein. There was no</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">statistically significant difference between the three groups in salivary flow rate and</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">Zn concentration. </span><strong><span style="font-size: 9.0pt; font-family: 'Times-Bold',serif; mso-bidi-font-family: Times-Bold;">Conclusion: </span></strong><span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">salivary pH, flow rate and Zn conc. can’t be used as</span>
<span style="font-size: 9.0pt; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">an indicator for occurrence of rampant caries but salivary total protein and salivary</span>
<span style="font-size: 9.0pt; line-height: 107%; font-family: 'Times-Roman',serif; mso-bidi-font-family: Times-Roman;">buffering capacity may be used.</span>
Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Combined Photothermal and Nanochemotherapy in Treatment of Induced Oral Squamous Cell Carcinoma in Hamsters778815293310.21608/dsu.2021.32548.1040ENRanda El-sherbinyDepartment of Oral Pathology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.Magda HassanDepartment of Oral Pathology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.Wafaa El-HossaryDepartment of Oral Pathology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.Mona ShataDepartment of Oral Pathology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.Journal Article20200728 <strong>Introduction: </strong>Oral squamous cell carcinoma (OSCC) shows unsatisfied survival rate which remains not changed over the last years. Thymoquinone (TQ) is a phytochemical, and many studies proved its promising therapeutic effect against OSCC. Gold nanorod (GNR) is a photothermal agent, has an efficient near-infrared heat conversion and induces ablation of solid tumors. The combination of photothermal therapy (PTT) and chemotherapy can enhance synergistic effects that markedly exceed the sum of individual treatments alone. <strong>Aim: </strong>this study aimed to evaluate the effect of combined photothermal and nano chemotherapy in treatment of induced oral squamous cell carcinoma in hamsters. <strong>Material and Methods: </strong>In the present study, the combined drug GNR/NTQ loaded on (poly) (lactic-co-glycolic acid) (PLGA) was prepared. The targeting agent, folate or folic acid (FA), was conjugated to the prepared nanoparticles. The therapeutic activity of the drug against chemically-induced OSCC in hamster buccal pouches was evaluated by clinical observations, tumor volume analysis, histopathological alterations and blood analysis. <strong>Results: </strong>The combined drug (GNR/NTQ/PLGA/FA/laser) had the highest therapeutic activity compared to individual treatments. It significantly ablated and regressed tumor size in chemically-induced OSCC in the hamster model as compared to the other preparations; GNR/NTQ/PLGA/FA without laser, GNR/ PLGA/FA/ laser and NTQ/PLGA/FA/laser. <strong>Conclusion: </strong>Compared to the single PTT or nanochemotherapy, the combined PTT/nanochemotherapy with laser provides better therapeutic effects against OSCCSuez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301The Effect of Nano-hybrid Composite Resin Denture Teeth on Mandibular Residual Ridge899515293410.21608/dsu.2021.40818.1044ENMaha Moussaremovable prosthodontics, faculty of dentistry, suez canal universityMoataz Elmahdyremovable prosthodontics department,faculty of dentistry, suez canal university, ismaillia, egyptSayed El Masryremovable prosthodontics department,faculty of dentistry, suez canal university, ismaillia, egyptHala Aliremovable prosthodontics department,faculty of dentistry, suez canal university, ismaillia, egypt0000-0002-5035-5315Journal Article20200907
<strong> Introduction:</strong>Progressive ridge resorption is one of the main causes of loss of stability and retention of mandibular complete dentures with subsequent loss of masticatory efficiency and patient discomfort. <strong>Aim: </strong>This study was conducted to evaluate radiographically the effect of nano-hybrid composite resin teeth on mandibular residual ridge using cone beam computerized tomography (CBCT). A comparative study. <strong>Materials and Methods: </strong>Twelve completely edentulous male patients were randomly divided into two groups according to the artificial tooth material used in complete denture construction. One group received complete dentures with nano-hybrid composite resin teeth and the other group received complete dentures with cross-linked acrylic resin teeth. CBCT was taken at the delivery, 6 months and 12 months follow -up appointments. The evaluation was done for height and width changes of the mandibular residual alveolar ridge at different anatomical sites either in the anterior or posterior part of the mandible. <strong>Results: </strong>Analysis was done by using two-tailed t-test revealed that increase in amount of bone loss in both groups which is in favor to patients wearing dentures with nano-hybrid composite resin teeth, with no statistically significant difference between the two groups. <strong>Conclusion: </strong>Despite of introduction of new denture tooth material as nano-hybrid composite resin teeth, the cross-linked acrylic resin teeth still considered the gold standard denture teeth regarding the degree of occlusal force transmission and preservation of residual alveolar ridge.Suez Canal University, Faculty of DentistryDental Science Updates2636-38362120210301Effect of Different Locator heights on peri-implant bone changes in Mandibular implant retained Overdenture9710415293510.21608/dsu.2021.45417.1049ENHelmy HassanAbdelhafizremovable prothodontic , faculty of dentistry, suez canal university0000-0002-2244-2227Moataz Elmahdydepartment of prosthodontics, faculty of dentistry, suez canal university, ismaailia, egypt.Sayed Elmasrydepartment of prosthodontics, faculty of dentistry, suez canal university, ismaailia, egypt.Hala MohamedAbd El-HamidRemovable prosthodontics faculty of dentistry Suez canal University, Ismailia, Egypt0000-0002-5035-5315Journal Article20201006 <strong>Introduction: </strong>The implant supported overdentures offered better chewing and masticatory functions. Locator attachment has more advantages than other attachment types<strong>. Aim: </strong>The aim of the study was to compare radio-graphically the effect of implant locator’s height on peri-implant bone height and density in mandibular over-denture. <strong>Patients and method: </strong>Twelve completely edentulous male patients had received conventional complete maxillary dentures and mandibular overdenture that retained by two implants that were inserted in the canine region by the help of CAD/CAM based surgical guides. The patients were divided randomly into two groups. Group I: the patients were received locator abutment with 1mm in height. Group II: the patients were received locator abutment with 3mm in height, a series of cone beam radiographs were taken at 0, 6, 12 and 18 months starting from the first day of lower over denture installation, peri-implant bone changes regarding height and density were estimated. <strong>Results: </strong>It was found that the mean marginal bone loss measurements were relatively higher for group I than group II with non-statistical significant difference. The average difference in bone density measurements around the implants for both groups showing initial increase followed by marked decrease through the follow up periods. <strong>Conclusion: </strong>locator height has an effect on peri-implant bone height, bone density.